Model-Based Inference of Haplotype Block Variation
نویسندگان
چکیده
منابع مشابه
Robustness of Inference of Haplotype Block Structure
In this report, we examine the validity of the haplotype block concept by comparing block decompositions derived from public data sets by variants of several leading methods of block detection. We first develop a statistical method for assessing the concordance of two block decompositions. We then assess the robustness of inferred haplotype blocks to the specific detection method chosen, to arb...
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During last years there has been a breakthrough in genetics and biotechnology. Present technology allows large scale association studies between genotypes and diseases. The most powerful methodology of association studies is the analyse of single nucleotide polymorphisms (SNPs). The estimated number of SNPs in the human genome is 10 million. Therefore, SNP markers provide practical fine-grain m...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2004
ISSN: 1066-5277,1557-8666
DOI: 10.1089/1066527041410300